Pan Z, et al. - In this retrospective review, researchers explored the connection between significant asymptomatic carotid artery stenosis (ACAS) and the severity of peripheral arterial occlusive disease (PAOD) in the lower limb, and examined the risk factors for significant ACAS in lower limb PAOD patients. The study sample consisted of 200 individuals with lower limb PAOD. Baseline data, medical history, and potential risk factors were collected for analysis. Patients with significant ACAS were significantly older in age relative to patients with non-significant ACAS, and they demonstrated a higher percentage of cigarette smoking and alcohol consumption as well as higher levels of total cholesterol and fibrinogen. In patients with lower limb PAOD, advanced age and hypercholesteremia seemed to be potential risk factors for significant ACAS. The stroke prevalence rate increased with ACAS stage. No significant difference was found with respect to sex, diabetes, hypertension, coronary heart disease, and triglyceride levels between the two groups.