Wang M, et al. - Experts wanted to validate and compare CONFIRM score and Genders extended model (GEM) for reliably estimating pretest probability (PTP) of obstructive coronary artery disease (CAD) among individuals with low traditional risk factor (RF) burden. They enrolled symptomatic individuals with 0 or 1 RF who had coronary calcium scan and coronary computed tomographic angiography (CCTA). A more accurate estimation for PTP was provided by the addition of coronary calcium score in individuals at low extreme of traditional RF burden of CAD and unnecessary testing could be avoided by the application of GEM instead of CONFIRM score.