Schoepf IC, Thorball CW, Ledergerber B, et al. - The present study was conducted to evaluate coronary artery disease-associated and longevity-associated polygenicLongevity-associated polygenic risk scores for prediction of coronary artery disease (CAD) events in persons living with HIV. Researchers ascertained univariable and multivariable odds ratios for CAD events, based on traditional CAD risk factors, adverse antiretroviral exposures, and different validated genome-wide polygenic risk scores (PRS) in Swiss HIV Cohort Study participants of self-reported European descent. In this study, 269 cases with CAD events were enrolled between 2000-2017 (Median age 54 years, 87% male, 82% with suppressed HIV RNA) and 567 event-free controls. The results showed that CAD prediction based on traditional and HIV-related risk factors was superior to genetic CAD prediction based on longevity- and CAD-associated PRS in Swiss people with HIV. It has been reported that combining traditional, HIV-related and genetic risk factors provided the most powerful CAD prediction.