Yared GS, et al. - Researchers focused on the link between left ventricular (LV) function and coronary artery calcium (CAC) in middle age and change in CAC from early adulthood to middle age. Using computed tomography, measurements of CAC score were obtained in the CARDIA study (Coronary Artery Risk Development in Young Adults) year-15 examination of 3,043 subjects and at year-25 examination in 3,189 subjects. As a continuous variable, the CAC score was evaluated and log-transformed to account for nonlinearity. Higher LV mass and volumes and worse LV diastolic function were observed in relation to higher CAC in middle age. Findings revealed a correlation of better LV function at middle age with being free of CAC from young adulthood to middle age. An independent association of higher change in CAC score during follow-up with higher LV mass index was found in blacks.