Knudsen AD, et al. - The proposition explored was that calibrated mass score (cMS) would detect low-level coronary artery calcification (CAC) not detectable with Agatston score (AS) in a large asymptomatic background population. Enrollees were grouped according to the number of traditional risk factors and heart score was used to assess the risk of an event for those with no CAC, those with only cMS > 0 and those with both AS and cMS > 0. Results demonstrated that in individuals with AS = 0, a fraction appeared to have cMS > 0. According to traditional risk factors, this group illustrated a higher 10-year risk compared to subjects with both AS = 0 and cMS = 0. It was also determined that cMS could offer very early cardiovascular risk assessment in asymptomatic individuals.