Leonardi A, Carraro G, Modugno RL, et al. - Among 14 patients with Fabry disease [FD] (mean age, 46.8 years) and eight healthy controls (mean age, 36.75 years), researchers compared the diagnostic power of slit-lamp examination with the in vivo corneal confocal microscopy (IVCM) as the gold standard in evaluating the presence of corneal epithelial deposits. Study participants had a slit-lamp examination and IVCM of both central and peripheral corneal quadrants with the Heidelberg Retina Tomograph-III in combination with the Rostock Cornea Module. Findings suggested that the slit-lamp exam has limited diagnostic power in detecting epithelial deposits in FD patients compared with IVCM. In fact, the slit-lamp examination suffers from a high number of false-negative outcomes and therefore from a low negative predictive value. IVCM enables corneal microstructural modifications to be detected in FD patients and can be a reliable instrument for early diagnosis and disease follow-up.