Kavoussi PK, Machen GL, Gilkey MS, et al. - In this retrospective chart review, researchers sought to assess outcomes including libido, semen parameters, testosterone, estradiol (E2), follicle stimulating hormone (FSH), and luteinizing hormone when converting men with low libido on clomiphene citrate (CC) to Natesto. Baseline hormones prior to treatment, and again on CC and Natesto, as well as semen parameters on CC and on Natesto, have been evaluated. Men on CC and Natesto achieved eugonadal testosterone levels, however, on CC the E2 level almost doubled from baseline, and converting men from CC to Natesto returned E2 to almost baseline levels. There was no adverse effect on semen parameters and subjective reporting of improved libido after conversion from CC to Natesto in this cohort, but more long-term studies are required before Natesto is identified as a definitive treatment for hypogonadism for men wishing to preserve fertility.