Clausen CS, Ljubicic ML, Main KM, et al. - In this pilot study, researchers sought to present the use of 17-hydroxyprogesterone (17-OHP) and androgen metabolites expressed as standard deviation (SD) scores rather than actual concentrations as a tool in the management of children with congenital adrenal hyperplasia (CAH) as well as in research settings. This investigation was conducted in a single, tertiary center. The sample consisted of 38 children and adolescents aged 3 to 18 years with CAH due to 21-hydroxylase deficiency. According to this retrospective, longitudinal study, applying sex- and age-related SD scores to 17-OHP and androgen metabolite concentrations allows for monitoring of hydrocortisone treatment regardless of age, sex, assay, and center. The authors recommend that 17-OHP and androgen metabolites expressed as SD scores be introduced as a unifying tool that simplifies study and, in the future, also optimal management of treatment.