Sun M, Tang C, Liu J, et al. - Researchers analyzed suppressor of cytokine signaling (SOCS) proteins in breast invasive carcinoma (BRCA), via a comprehensive bioinformatic analysis. They found in BRCA tissues that SOCS2 and SOCS3 exhibited significantly lower mRNA expression levels, vs normal tissues. Significantly longer overall survival times were predicted for BRCA patients with high mRNA levels of SOCS3 and SOCS4. The factors that were predicted to be significantly related to better recurrence-free survival included: high mRNA expression levels of SOCS2, SOCS3, and SOCS4, and a low expression level of SOCS5. Overall, findings demonstrate a very essential role of SOCS family proteins in BRCA. It was inferred that SOCS3 may serve as a prognostic factor and SOCS2 may represent a potential treatment target in breast cancer.