Bao X, et al. - Researchers investigated the possible link between elevated C3 concentration and hospitalization due to chronic kidney disease (CKD), as well as the impact of diabetes and hypertension as mediating factors on this link in the general population comprising 4,552 participants, without previous hospital admission due to CKD, from the Malmö Diet and Cancer cohort study. A mean follow-up of 19.2 ± 4.16 years was carried out, at the end of which, the link between C3 levels and incidence of first hospitalization due to CKD (main diagnosis) was determined using Cox proportional hazards regression models. The CKD-related hospitalization was reported in 94 subjects during the follow-up. According to the findings, C3 was related to the incidence of first hospitalization due to CKD in this study population. Hyperglycemia and hypertension could not completely account for the observed link.