Fuest K, Dorfhuber F, Lorenz M, et al. - High-quality cardiopulmonary resuscitation (CPR) can be performed with the help of automated mechanical chest compression devices (AMCCDs). As CPR guidelines do not have information concerning the optimal ventilation mode during CPR using AMCCDs, researchers sought to compare three common ventilation modes during CPR using AMCCD. In this randomized controlled trial, they performed random assignment of patients with an out-of-hospital cardiac arrest arriving at the resuscitation room receiving chest compressions via AMCCD with an expected continuation of at least 15 min, to following three groups: biphasic positive airway pressure with assisted spontaneous ventilation (BIPAP) with assisted spontaneous breathing, continuous positive airway pressure (CPAP) and volume-controlled ventilation (VCV). An adequate respiratory minute volume was achieved in all ventilation modes during CPR with an AMCCD. However, BIPAP appears superior because of higher tidal volume. Hnce, researchers favor initiating mechanical ventilation when employing AMCCD with BIPAP ventilation to avert risks related to dead space ventilation.