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Comparison of therapeutic effects between artificial dermis combined with autologous split‐thickness skin grafting and autologous intermediate‐thickness skin grafting alone in severely burned patients: A prospective randomized study

International Wound Journal Nov 05, 2020

Shang F, Lu YH, Gao J, et al. - Researchers aimed at examining the therapeutic effects of artificial dermis combined with autologous split‐thickness skin grafting (STSG) vs autologous intermediate‐thickness skin grafting (ITSG) alone in severely burned patients. They enrolled 56 severely burned patients and grouped them evenly according to the random number table method [AD‐STSG group: 28 patients, receiving the treatment of artificial dermis (AD) combined with autologous STSG; ITSG group: 28 patients, receiving autologous ITSG treatment alone]. All enrolled patients were evaluated for the healing time and Vancouver Scar Scale score of the donor area and graft area, survival rate and infection status of the autologous skin, psychological status (determined by Self‐rating Anxiety Scale and Self‐rating Depression Scale), and the activity of functional parts. Overall findings revealed better therapeutic outcomes for the treatment of severely burned patients in correlation with receiving artificial dermis combined with autologous split‐thickness skin grafting vs autologous intermediate‐thickness skin grafting in terms of graft healing time, scar formation, psychological recovery, and perhaps in functional reconstruction.

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