Noaman S, et al. - In 3,283 ST-elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PCI) in the Victorian Cardiac Outcomes Registry, researchers compared clinical outcomes of those with proximal lesion location vs those with nonproximal location. A total of 1,376 (41.9%) participants had a proximal lesion location. Greater rates of cardiogenic shock and out-of-hospital cardiac arrest, and left ventricular systolic dysfunction were reported in patients with proximal lesion location. Similar procedural success rates were reported. Also, higher rates of in-hospital and 30-day mortality, major adverse cardiac events (MACE; mortality, myocardial infarction, stent thrombosis, and unplanned revascularization) and major adverse cardiac and cerebrovascular events (MACCE; MACE, and stroke) were observed in patients with proximal lesion location vs those in the nonproximal group. However, no independent association of proximal lesion location with MACE during in-hospital stay or at 30-days was seen in multivariable regression analysis.