Hage C, et al. - The role of insulin-like growth factor-binding protein 7 (IGFBP-7) in heart failure (HF) pathophysiology was characterized herein. Researchers noted that IGFBP-7 was elevated in patients with HFrEF. In these subjects, IGFBP-7 showed an association with HF severity but not prognosis, suggesting a marker of risk. On the contrary, patients with HFpEF exhibited less elevated IGFBP-7 and its association with markers of diastolic dysfunction, HF severity, and prognosis. Possibly via inflammation and oxidative stress, IGFBP-7 may contribute to progression of HFpEF.