Fujiwara T, et al. - A comparative inspection was carried out of the impact of morning and bedtime administration of valsartan/amlodipine combination therapy (80/5 mg) on nocturnal brachial and central blood pressure (BP) estimated via ambulatory BP monitoring in patients with hypertension. It was observed that the upper limit of the 95% confidence interval was below the margin of 3.0 mm Hg in both nocturnal brachial and central systolic BP. This data ascertained the noninferiority of morning administration to the bedtime administration of valsartan/amlodipine combination therapy.