Sawasdiwipachai P, Weerayutwattana R, Thongcharoen P, et al. - Researchers undertook this prospective randomized cross-over trial to determine whether high-flow humidified oxygen (HFHO) has efficacy as an alternative for continuous positive airway pressure (CPAP) for improving oxygenation while preserving non-ventilated lung collapse during one-lung ventilation. Participants were 28 patients receiving elective thoracotomy with one-lung ventilation employing a double-lumen endobronchial tube placement. Worsening of the surgical condition was seen in half of the patients undergoing CPAP, while HFHO patients felt no change or stated a better lung deflation. Findings indicate that for improving arterial oxygenation while preserving lung deflation during one-lung ventilation, HFHO could serve as an alternative method to CPAP. However, regarding its cost-effectiveness as well as establishment as a routine treatment, further investigations are warranted.