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Comparison of DNA damage and oxidative stress in patients anesthetized with desflurane associated or not with nitrous oxide: A prospective randomized clinical trial

Anesthesia & Analgesia Mar 26, 2018

Nogueira FR, et al. - In patients who underwent an elective minimally invasive surgery, researchers compared the impacts of anesthesia maintained with desflurane associated or not with nitrous oxide (N2O) on DNA damage (as a primary outcome) and oxidative stress (as a secondary outcome). The effects on DNA or the redox status did not seem to be impaired when desflurane was coadministered with 60% N2O, compared with desflurane anesthesia. This indicated that both studied anesthetic techniques can be suitable options for healthy individuals who undergo minimally invasive surgery lasting at least 1.5 hours.
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