Ohno Y, et al. - Using standard-dose, reduced-dose and ultra-low dose chest CTs with and without adaptive iterative dose reduction 3D (AIDR 3D), experts directly compared the effect of a reconstruction algorithm on nodule detection capability of the computer-aided detection (CADe) system. Even when radiation dose was reduced, the AIDR 3D had a significant positive effect on nodule detection capability of the CADe system.