Gibson AJW, et al. – Using data from the institutional Glans-Look Lung Cancer Database that were analyzed between January 1999 and December 2013, researchers assessed 185 relapsed and 3,039 de novo cases of metastatic non–small cell lung cancer (NSCLC) to determine the clinical aspects and consequences of the relapsed and de novo NSCLC. They observed the patterns of smoking history, histology, systemic therapy use, and disease extent between the two categories of cases. They noticed a longer median overall survival and notable improvements as consequences among relapsed cases and poorer survival of de novo cases. Overall, they suggested screening initiatives beamed at reducing de novo disease prevalence.