Roof MA, Baylor JL, Bernstein J, et al. - In this study, the real-component was compared with all-cement articulating spacers for total knee arthroplasty (TKA) periprosthetic joint infection (PJI) treatment. Between April 2011-August 2020, researchers performed a retrospective observational study to analyze the arthroplasty database at three academic hospitals for articulating spacers placed for TKA PJIs. Individuals were classified as receiving a real-component or an all-cement articulating spacer. Data on demographics, surgical information, and outcomes were collected. They distinguished 164 spacers: 72 all-cement and 92 real-component. This study’s findings demonstrate that real-component spacers had improved ROM after stage 1 and lower blood loss, shorter operative time, and shorter hospital stay after stage 2 compared to all-cement articulating spacers. In ROM, the two spacer constructs had the same ultimate change and no variation in reinfection rates, highlighting that both articulating spacer types may be safe and effective options for two-stage revision TKA.