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Comparative effectiveness of three exercise types to treat clinical depression in older adults: A systematic review and network meta-analysis of randomised controlled trials

Ageing Research Reviews Dec 18, 2019

Miller KJ, et al. - Via performing a systematic review and network meta-analysis of current evidence from randomised controlled trials (RCTs), researchers sought to determine the comparative efficacy of three major exercise types (resistance, aerobic, and mind-body exercise) in clinically depressed older adults. Following PRISMA-NMA guidelines, databases (inception – June 30th, 2018) were searched including 15 eligible RCTs comprising 596 participants (321 treatment and 275 controls) in this network meta-analysis; these RCTs included aerobic (n = 6), resistance (n = 5), and mind-body (n = 4) exercise trials. Outcomes revealed that benefits were provided by aerobic, resistance or mind-body exercise among older adults; this presents an opportunity to patients to select their preferred type(s) of exercise. For treating clinical depression, exercise is a therapeutic ally to pharmacological treatment. High compliance and tolerance of exercise were evident in pooled NMA evidence.
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