Rokkas T, Gisbert JP, Malfertheiner P, et al. - Because a number of double, triple and quadruple therapies have been proposed as first-line H. pylori infection empiric treatments, researchers used a network meta-analysis (NWM) of published RCTs to assess the comparative effectiveness of all empirically used first-line regimens tested against standard triple treatment. Data extracted from eligible RCTs were entered into a Bayesian NWM to examine the comparative effectiveness of H. pylori infection empiric first-line regimens and to examine their effectiveness rank order. Sixty-eight eligible RCTs were involved, giving a total of 92 paired comparisons with 22,975 patients, randomized to eight first-line regimens. Vonoprazan triple therapy and reverse hybrid therapy achieved more than 90% eradication rates for first-line empiric H. pylori infection treatment. In Western countries, levofloxacin triple therapy achieved the highest eradication rates. In this NWM, standard triple therapy was the least effective regimen.