Xu Y, Zhao H, Tong Y, et al. - This study was carried out to evaluate the discrepancy in clinicopathological characteristics and protein expression between esophageal basaloid squamous cell carcinoma (BSCC) and typical esophageal squamous cell carcinoma (SCC). In this study, 40 cases of esophageal BSCC were examined. Researchers selected 63 well-differentiated SCC patients, 70 moderately differentiated SCC patients, and 51 poorly differentiated SCC patients as controls. They further assessed the clinicopathologic characteristics and immunoreactivity of Ki-67, p53, p63, and epidermal growth factor receptors in the BSCC and typical SCC patients. The data demonstrate that esophageal BSCC has a more clinically virulent course. The results show that p53 and p63 expressions are associated with prognosis in BSCC. These outcomes illustrate that assessment of multiple cancer biomarkers might be a promising auxiliary diagnostic indicator in BSCC.