Viereck V, Gamper M, Walser C, et al. - The combination of botulinum toxin and polyacrylamide hydrogel proved to be effective, sustainable, and safe to treat therapy-refractory mixed urinary incontinence (MUI), even in the elderly and frail study population. Patients benefit from the short surgical procedure without the need for general anesthesia or discontinuation of anticoagulation.

• For stress urinary incontinence (SUI), urgency urinary incontinence (UUI), and MUI, objective cure rates were 73%, 53%, and 42%, and subjective cure rates were 71%, 52%, and 50% at 4 months.

• According to the findings, 73%, 56%, 50% were the objective cure rates, and 78%, 42%, and 40% were subjective cure rates for SUI, UUI, and MUI at 12 months.

• It was shown that the International consultation on incontinence questionnaire-urinary incontinence short form score decreased by 9.0 and 8.7 points after 4 and 12 months.

• After surgery, all complications were transient and included 22% clean intermittent catheterization immediately, 33% postvoid residual volumes >100 ml at 14 days, and 13% symptomatic urinary tract infection within the first postoperative month.