Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: The GOMAP study
BMC Psychiatry Aug 08, 2018
Mamakou V, et al. - Given the association of schizophrenia (SCZ) with an increased risk of type 2 diabetes (T2D), researchers undertook the Genetic Overlap between Metabolic and Psychiatric disease (GOMAP) study assessing the effect of pharmacological, anthropometric, lifestyle and clinical measurements to describe mechanisms underlying the etiology of T2D. They analyzed 1,653 patients with SCZ (611 with T2D and 1,042 patients without T2D). For the first time, SCZ and T2D comorbidity at this scale was addressed in the Greek population. As per findings, SCZ patients taking a combination of at least three different psychotropic medication classes were at increased risk of T2D compared to patients whose medication consists only of one or two classes of drugs.
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