Jadli A et al. – This study evaluated combination of copeptin (CPP), placental growth factor (PIGF), and total annexin V microparticles (MPs) as biomarkers for prediction of preeclampsia (PE) at 10 to 14 weeks of gestation. The authors concluded that the combination of these biomarkers and microparticles can be used for prediction and discrimination of PE from other pregnancy complications at 10 to 14 weeks.

Methods

• Women who subsequently developed PE (n = 33), intrauterine growth restriction (n = 81), and normal pregnancy outcome (n = 112) at 10 to 14 weeks of gestation were evaluated for serum levels of CPP, PIGF, and plasma total annexin V MPs.

Results

• Elevated levels of total annexin V MPs (2766.04 [2086.88–3794] vs 1090.74 [631.91–2197.16]) and CPP (440.98 [365.12–488.92] vs 217.8 [171.13–308.98]) were reported in women who subsequently developed PE, compared with controls.
• Women with PE revealed significantly reduced PIGF levels (17.68 [12.66022.32]) compared with controls (105.22 [35.02–255.1]).
• Combination of CPP, PIGF, and total annexin V MPs showed high predictive value for PE prediction at 10 to 14 weeks.