Chaseling GK, et al. - Herein, the authors examined if cold-water ingestion blunts exercise-induced increased in body temperature and caused an improvement in the exercise tolerance in heat-sensitive individuals with multiple sclerosis (MS). An enhancement was yielded in the exercise tolerance of MS patients via cold-water ingestion in the heat by ∼30% despite no variations in the core and mean skin temperatures or heart rate. Hence, the use of a simple cooling strategy was recommended for mitigating heat intolerance with MS. The findings provided insight into the potential role of cold-afferent thermoreceptors that resided in the abdomen and oral cavity in the modulation of exercise tolerance with MS in the heat.