Donadeu L, Revilla-López E, Jarque M, et al. - In view of the observations suggesting the value of monitoring CMV-specific Cell-mediated immunity (CMV-CMI) in predicting late-onset CMV infection in different solid organ transplants, researchers here evaluated CMV-CMI against two major CMV antigens (IE-1, pp65) in 60 seropositive lung transplantation (LT) at 6-month prophylaxis withdrawal. They noted significantly lower (IE-1) CMV-CMI in LT with late-onset CMV infection vs patients who did not, being more evident in patients developing high viral loads. Notably, Independent predictive value of (IE-1) CMV-CMI for high first late-onset viral replication was evident. CMV-specific CMI seems to be a valuable new immune tool that may guide in CMV preventive strategies after LT.