Lantis JC, et al. – An assessment and comparison were carried out of the clinical effectiveness of clostridial collagenase ointment (CCO) with standard care (SC) in patients with diabetic foot ulcers (DFUs). The intent was to define the best clinical criteria for the utility of CCO in the study cohort. A correlation was brought to light between active CCO therapy with a nonstatistically greater reduction in wound size than any of the passive or mechanical SC modalities at end of the therapy. This was found to be prominent when used in conjunction with sharp debridement and for slow healing ulcers, larger sized wounds or plantar surface wounds.