Clinicopathological features of Epstein-Barr virus–associated superficial early stage gastric cancer treated with endoscopic submucosal dissection
Digestive and Liver Diseases Sep 17, 2021
Suzuki Y, Inoshita N, Kikuchi D, et al. - The prevalence and clinicopathological features of Epstein-Barr virus (EBV) -associated early gastric carcinoma (EBVEGC) are described.
A total of 618 lesions in 519 patients treated with ESD were reviewed.
In situ hybridization staining was performed on tissue microarray sections for EBV-encoded small RNA transcripts (EBER).
EBVEGC was identified in 1.9% of the lesions.
EBVEGCs were more often located in approximation to the atrophic border in the middle or upper stomach and were reddish.
Deeper invasion and more often undifferentiated histology were identified in EBVEGC.
On narrow-band imaging magnifying endoscopy, researchers identified an endoscopic lace pattern, defined as an absent or obscure microsurface pattern and a microvascular pattern of a tiny, dense, and irregular subepithelial capillary network, significantly more often in the EBVEGC group.
The EBVEGC group had significantly lower rate of curative resection.
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