Jordan CS, et al. - In this retrospective review, researchers compared the histological and immunophenotypic characteristics of central centrifugal cicatricial alopecia (CCCA) and lichen planopilaris (LPP) to better characterize and differentiate these two clinical entities. The sample consisted of 51 scalp biopsies of patients with either the clinical diagnosis of CCCA (27 cases) or LPP (24 cases). Clinical information, histologic features of hematoxylin-eosin-stained sections, and a panel of immunohistochemical markers have been assessed on scalp biopsies. No differences on either histologic assessment or immunophenotypic characterization between cases of classic LPP and CCCA were observed. Overall, the authors concluded that the inflammatory infiltrates in CCCA and LPP were not only histologically comparable but also immunophenotypically indistinguishable.