Fan L, Yang L, Wei D, et al. - In this largest current real-world scenario, interventions were needed in over two-thirds of patients with childhood Takayasu arteritis (TAK), and 5-year complication-free survival was 50.7%. Dual antiplatelet therapy (DAPT) peri-intervention seems prophylactic against postinterventional complications.

• This study involved 101 patients with childhood TAK, of whom 69 (68.3%) received 121 interventions (angioplasty 95, stenting 26) during a 3.1-year follow-up.

• The technical success rate was 96.7%, and main clinical hints for interventions included hypertension secondary to renal artery stenosis (RAS; 59.4%) or mid-aorta stenosis (MAS; 14.5%).

• Post-intervention follow-up revealed that 36 lesions occurred with complications in 28 cases, and 22 lesions in 17 cases, specifically on the renal artery or mid-aorta; 5-year complication-free survival was 50.7% and 5-year reintervention-free survival was 65.8%.

• Independent predictors for complications included: peri-interventional DAPT (hazard ratio [HR] 0.31), concurrent surgery (HR 26.5), and technical failure (HR 3.65).

• The likelihood of unfavorable results was indicated by male gender (HR 2.52), retinopathy (HR 3.41), and pulmonary artery hypertension (HR 3.64) at baseline.

• In childhood TAK, interventions on MAS or RAS raise specific concerns.