Hong DK, et al. - Researchers examined clinical outcomes in high-grade cervical intraepithelial neoplasia (CIN) diagnosed by colposcopy-directed biopsy during pregnancy in this retrospective study. They also examined the risk factors associated with the persistent disease. They identified 215 pregnant women who were diagnosed with high-grade CIN (75 CIN2, 140 CIN3) by colposcopy-directed biopsy during the 10-year period, 187 of whom had high-risk HPV infections, and 76 infections were recognized as HPV genotype 16 or 18. Observations suggest that during pregnancy, conservative management of CIN2-3 is satisfactory, but for CIN2+ persistence, a major risk factor was persistent high-risk human papillomavirus (HPV) infection. They emphasize performing close follow-up with HPV testing, and postpartum colposcopy evaluation.