Grant S, Azhar G, Han E, et al. - The available evidence on the effectiveness of clinical interventions for patients diagnosed with both an alcohol use disorder (AUD) and depressive disorder are reviewed.

• A systematic review and network meta-analysis (NMA) of 36 randomized controlled trials (RCTs) with 2,729 participants.

• A total of 14 pharmacological and 4 psychological interventions for adults with co-occurring AUDs and depressive disorders were evaluated.

• All estimates of intervention effects on the primary outcomes (ie, remission from depression and remission from alcohol use) appeared very less trustworthy.

• Cognitive behavioral therapies (CBTs) possibly reduced, and tricyclic antidepressants (TCAs) possibly resulted in a slight reduction in depressive symptoms, selective serotonin reuptake inhibitors (SSRIs) possibly improved functional status, SSRIs and CBTs may linked with a slight decrease in alcohol use, and SSRIs also likely resulted in an enhanced risk of experiencing an adverse event.

• A very low trust was built in all other effect estimates, and there was no high confidence in any effect estimates.