Guani B, Mahiou K, Crestani A, et al. - Researchers conducted a comprehensive meta-analysis of published data and individual data obtained from articles mentioning micrometastases (MIC) and isolated tumor cells (ITC) in cervical cancer, with a follow up of at least 3 years, with the aim to define the clinical significance of low-volume metastasis.

• For the meta-analysis, a total of 11 articles were retained.

• Findings suggest an association of the presence of micrometastases with a negative impact on disease-free survival.

• Researchers recommend considering patients with isolated tumor cells like negative lymph node patients.