Clinical impact of KMT2C and SPRY4 expression levels in intensively treated younger adult acute myeloid leukemia patients
European Journal of Haematology Sep 28, 2017
Kayser S, et al. - This study aimed at investigating the prognostic impact of gene expression levels (ELs) of two tumor suppressor genes, sprouty 4 (SPRY4, located on 5q) and lysine methyltransferase 2C (KMT2C, located on 7q) in correlation to clinical characteristics and genetic abnormalities assessed at initial diagnosis in acute myeloid leukemia (AML). Findings suggested an association of KMT2C ELs with specific genetic features and that SPRY4 ELs might add prognostic information.
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