Toce MS, Freiman E, O’Donnell KA, et al. - Researchers conducted a retrospective cohort study to provide a descriptive analysis of the rates and times to vital sign abnormalities, treatment, disposition, and outcomes in a single-center cohort of pediatric patients with a report of clonidine poisoning. Between January 2004 and November 2017, patients younger than 21 years who presented to a large, urban, tertiary care center with a report of single substance clonidine exposure were considered for this analysis. Eighty-eight patients met the criteria for inclusion. In this study of patients at a pediatric tertiary referral center, clonidine exposure-reported pediatric patients were likely to show altered mental status and to develop vital sign abnormalities frequently. Naloxone demonstrated some efficacy; given its wide safety margin, high-dose naloxone should be used in critically poisoned non–opioid-dependent patients. Since adolescents are far more likely to consume their own clonidine medication, it is important to warn parents and other caregivers about safe storage of the medication.