Abdel Salam Gomaa N, Helmy YAH, Maher S, et al. - Researchers conducted this retrospective case-control study to identify the risk factors that may predispose preterm neonates to develop aggressive posterior retinopathy of prematurity (APROP). This investigation involved 16 infants with APROP in zone 1 or posterior zone 2. A total of 34 gestational age and birth weight-matched controls with stage 2 or less ROP were included in the study. Being small for gestational age, consuming caffeine for a longer period of time, and having culture-proven sepsis were all linked to APROP. APROP was associated with IVH, low serum hemoglobin, the need for more plasma transfusions, and a longer duration of inotropes, all of which necessitated retreatment.