Rodríguez-Espinosa S, Coloma-Carmona A, Perez-Carbonell A, et al. - In this study, factors correlated with opioid withdrawal in patients with chronic non-cancer pain (CNCP) were explored. Researchers designed a cross-sectional descriptive study including a total of 404 patients who use prescription opioids for long-term treatment (≥ 90 days) of CNCP. Sociodemographic and clinical characteristics, prescription opioid use disorder (POUD), withdrawal symptoms, craving, anxiety-depressive symptoms, and pain intensity and interference were the outcome measures. The data demonstrate that psychological factors appear to play a key role in the severity of withdrawal symptoms. Knowing the factors correlated with withdrawal may be useful in developing preventive psychological interventions since the greater intensity of these symptoms increases the risk of developing POUD.