Monteverde T, Sahoo S, La Montagna M, et al. - Given that characteristics of chromosomal instability (CIN) are shown by ∼80% of solid cancers, including non-small cell lung cancer (NSCLC), researchers assessed the molecular mechanisms linking CIN to tumor progression. They conducted an RNAi screen on genes implicated in CIN and overexpressed in human lung adenocarcinoma samples. They found a potential oncogene, the cytoskeleton-associated protein 2-like (CKAP2L), that promotes lung cancer proliferation as well as growth in vitro and in vivo. An increased sensitivity of NSCLC cells to alvocidib (a pan CDK inhibitor) was conferred by depletion of CKAP2L, which ultimately resulted in a significant decrease of cell proliferation as well as an increase in cell death. Collectively, these data unveil the molecular mechanisms by which cancer progression is promoted by CKAP2L, a protein involved in CIN, and also indicated that its inhibition affords a novel treatment approach in NSCLC.