Zhu J, Ling Y, Tse LA, et al. - By applying Mendelian randomization (MR) design, researchers examined the possible causal links of vitamin C with major cardiovascular disease (CVD) events as well as their risk factors. To predict plasma vitamin C concentrations, nine genetic variants related to vitamin C at genome-wide significance (p < 5 × 10 ⁻⁸ ) were used. Coronary artery disease, atrial fibrillation, heart failure, and ischemic stroke were considered as primary outcomes. A causal protective role to circulate vitamin C levels on several types of CVD events is not supported by the findings of this MR study. The results of this investigation together with previous RCT findings indicate that CVD prevention may not be aided by raising circulating vitamin C levels via vitamin C supplementation.