Nicolazzo C, et al. - The final analysis outcomes of a single-center prospective study on the effect of circulating tumor cells (CTCs) on cancer-specific survival (CSS) and overall survival (OS) in 102 patients with high-grade T1 (HGT1) bladder cancer (with a median follow-up of 63 months) were reported by the researchers in this study. They found that shorter CSS and OS were predicted by the presence of even a single CTC, as compared with the standard predictive variables. They found CTCs offered an accurate risk stratification, which might be important for deciding the best surveillance strategy for patients following diagnosis. In patients with super-high-risk non-muscle-invasive bladder cancer, a closer follow-up, an early radical surgery, or even a systemic therapy might be advised.