Nicolazzo C, et al. - In 102 patients with high-grade T1 (HGT1) bladder cancer who were followed-up for a median duration of 63 months, how cancer-specific survival (CSS) and overall survival (OS) were influenced by circulating tumor cells (CTCs) was reported in this final analysis of a single-center prospective study. Researchers found that shorter CSS and OS were predicted by the presence of even a solitary CTC vs the usual predictive variables. For selecting the best surveillance strategy for patients after diagnosis, accurate risk stratification using CTCs might be helpful. In patients with super-high-risk non-muscle-invasive bladder cancer, a closer follow-up, early radical surgery, or even a systemic treatment might be advised.