Cao YX, Jin JL, Sun D, et al. - Three hundred and thirty-eight consecutive heterozygous familial hypercholesterolemia (FH; Dutch Lipid Clinic Network score ≥ 6) patients were recruited and followed up for the occurrence of major cardiovascular events to assess the prognostic value of plasma proprotein convertase substilisin/kexin type 9 (PCSK9) levels, and its ability to reclassify risk among individuals with FH in a Chinese FH prospective cohort. Researchers determined that elevated levels of PCSK9 were positively related to the development of CAD and future cardiovascular events, suggesting that for cardiovascular risk stratification, PCSK9 concentration measurements could be beneficial. Further studies, however, are warranted to replicate and validate these findings.