Leao R, Albersen M, Looijenga LHJ, et al. - This study was sought to systematically assess the evidence for clinical applications of serum levels of miR302/367 and miR371-3 in adult testicular germ cell tumours (GCTs) in terms of primary diagnosis, various clinical scenarios, and the costs of clinical implementation. Researchers conducted a critical review of PubMed/Medline, Embase and the Cochrane Library in January 2021 in accordance with Preferred Reporting Items for Systematic Review and Meta-analysis statement. They examined the current evidence on the usefulness of blood levels of molecules called microRNAs in the management of testicular tumours. The outcomes demonstrate that microRNA-371a-3p molecules have better sensitivity and specificity than the markers currently being measured. It has been considered that this new biomarker may soon have a place in clinical practice.