Xie SH, Rabbani S, Ness-Jensen E, et al. - Researchers conducted this systematic review and meta-analysis to explore connections between circulating levels of obesity-related biomarkers and risk of esophageal adenocarcinoma and Barrett esophagus by performing a literature search until October 2018 in MEDLINE and EMBASE. Utilizing random effect meta-analyses, they estimated pooled ORs with 95% confidence intervals for connections between 13 obesity-related inflammatory and metabolic biomarkers and risk of esophageal adenocarcinoma or Barrett esophagus. Among the 7,641 studies, 19 (12 cross-sectional, two nested case-control, and five cohort studies) were qualified for inclusion. For adiponectin, ghrelin, insulin-like growth factor 1, insulin-like growth factor-binding protein 3, triglycerides, IL8, or TNFα, no associations were established. An increased risk of esophageal adenocarcinoma or Barrett esophagus may be associated with higher circulating levels of leptin, glucose, insulin, CRP, IL6, and sTNFR-2. In order to identify biomarkers that can help fine high-risk people for targeted prevention and early detection, further prospective studies are required.