Schuldt EA, et al. - Herein, the association of angiopoietin-2 (Ang2) and Tie2 (Tyrosine kinase with Ig and EGF homology domains) with inflammation markers was investigated in the general population. A positive association of Ang2 with fibrinogen, high-sensitive C-reactive protein (hsCRP) and white blood cell count (WBC) was demonstrated. Furthermore, diverse postulated impacts of Ang2 on inflammation processes were also noted, which included increase of vascular leakage or influences on the adhesion of leukocytes to the vessel wall. The proinflammatory character of these impacts was similar to those of fibrinogen which conforms to the findings of relations between the markers.