Baiardini I, et al. - For assessment of patients with chronic urticaria (CU) in clinical practice, experts validated the Chronic Urticaria Patient Perspective (CUPP). This study outlined CUPP as a simple 10-question tool with good psychometric properties. This tool rendered a valid, reliable, and standardized measurement of health-related quality of life (HRQoL) in patients with CU.

Methods

• From candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires, a provisional CUPP was developed.
• Further to this, the psychometric properties of the CUPP were tested on a sample of patients enrolled in 13 Italian centers.

Results

• 152 patients were incorporated in the validation phase.
• Satisfactory internal consistency (Cronbach's alpha values of 0.76 at visit 1 and 0.90 at visit 2), good criteria, and discriminative and convergent validity were exhibited by the 10-item version of the CUPP.
• In 34 patients, reliability was assessed with no changes in health (Global Rating Scale = 0 at visit 2) and was satisfactory (CCC [concordance correlation coefficient] = 0.9).
• Results indicated an association of changes in CUPP scores with changes in Urticaria Activity Score (UAS)-Hive count (r = 0.36, P < .001), UAS-Itch severity (r = 0.48, P < .001), and UAS-Total score (r = 0.342, P < .001).
• All of these indicated good responsiveness.
• 1.5 was the minimal important difference.