Lupidi M, Fruttini D, Eandi CM, et al. - In patients with chronic central serous chorioretinopathy (CSCR), researchers compared optical coherence tomography–angiography performed during physical exercise (stress OCT-A) to the basal examination (rest OCT-A) in the imaging of choroidal neovascularization (CNV). Participants in the study were 29 consecutive individuals with chronic CSCR and flat irregular pigment epithelium detachments (FIPEDs). All individuals had rest and stress OCT-A (ie, hand-grip test [HGT]). During the examinations, systemic hemodynamic data were recorded. During the HGT, blood pressure significantly increased. According to the quantitative analysis, a significantly greater neovascular area and fractal dimension on the stress OCT-angiograms were recorded. The results obtained from this prospective, cohort study indicate that OCT-A performance during HGT enhances examination sensitivity in chronic CSCR detection of CNV. The increased neovascular perfusion following the induced blood pressure rise is consistent with choroidal dysregulation of blood flow in CSCR patients and suggests new areas of focus on CNV in this disease.