Moorthi RN, et al. - In order to test the hypothesis that early chronic kidney disease (CKD) is associated with altered sensory, motor and autonomic nerve function, researchers assessed the link between CKD and nerve function using logistic regression adjusted for covariates in participants in the Health, Aging and Body Composition cohort. CKD was found to be related to higher odds for vibration detection threshold and light touch insensitivity. Adjusted analyses revealed higher odds of an abnormal heart rate response and poor heart rate recovery among participants with CKD. Overall, even after adjustment for demographics and comorbidities, including diabetes, sensory and autonomic nerve function changes were reported in relation to CKD.